ZeptoMARK Reverse Arrays are the leading technology to screen compound efficacy at a cellular level for multiple pathways and downstream targets in a flexible and cost effective manner. Besides the targets of interest, corresponding stress and apoptosis pathway markers can be measured simultaneously, giving an indication not only of compound efficacy but also toxicity.

The effects of investigational compounds 1, 2 and 3 were tested on 5 signaling proteins. Compound 1 inhibited the expression/activation of all 5 proteins. Compound 2 showed inhibition of one protein, whereas Compound 3 had a stimulating effect on 4 of the 5 proteins investigated.

More details about this specific compound selectivity study can be read in the following application note:

Application Note: Multiplexed Compound Selectivity Profiling

Please contact Zeptosens if you are interested in a compound selectivity profiling study with Zeptosens in your specific field. Alternatively, Zeptosens can also provide you with the necessary system, chips and buffers to run multiplexed compound selectivity profiling studies in house.