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The comparison of standard levels of protein expression in different mouse models or mouse species, provide the researcher with new targets or biomarkers. In addition, treating mice with compounds and detecting the deviation from the "standard signalome" provides a clear indication of the effect of the compounds. 
More details about this specific biomarker study can be read in the following application note:
Generation of an Organ Specific Pathway Activity Atlas Please contact Zeptosens if you are interested in a study with Zeptosens to find biomarkers / targets in your specific field. Alternatively, Zeptosens can also provide you with the necessary system, chips and buffers to run biomarker studies in house.
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